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Challenges in Diagnosing Central Adrenal Insufficiency in Children: Cortisol-Stimulating Tests are Safe and Often Required
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DOI：10.1111/cen.70164.png)
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Abstract
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The accuracy and safety of cortisol-stimulating tests (CSTs) for assessing hypothalamic–pituitary–adrenal (HPA) axis integrity, including the diagnosis of central adrenal insufficiency (CAI), in children remain uncertain. Although these tests can simultaneously evaluate cortisol and growth hormone secretion, the present study focuses exclusively on cortisol measurements.
Keywords:
adrenal gland diseases
adrenal insufficiency
hypopituitarism
hypothalamic-pituitary-adrenal axis
pituitary gland
pituitary-adrenal function tests
pituitary-adrenal system
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