.png){kind=icon}
.png){kind=icon}
Return
Changes in Natriuretic Peptide Levels and Cardiac Structure in Patients Treated With Vericiguat ― VERIFY-HF Registry ―
.png){kind=icon}
PRE
AI
K
K
N
W
N
S
I
I
K
M
DOI：10.1253/circj.CJ-25-1087.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Background: Changes in N-terminal pro B-type natriuretic peptide (NT-proBNP) levels and cardiac remodeling from baseline to follow-up in patients with heart failure with reduced ejection fraction (HFrEF) treated with vericiguat remain unclear. Methods and Results: The VERIFY-HF registry is a nationwide multicenter retrospective single-arm study of patients with HFrEF newly prescribed vericiguat at 22 hospitals in Japan. In this study, we analyzed baseline and follow-up echocardiography findings of 504 patients. Vericiguat dose-dependently reduced NT-proBNP levels, with a greater reduction in those receiving 7.5 or 10 than <= 5mg vericiguat (NT-proBNP least-squares geometric mean ratio [3 months/baseline] 0.53 vs. 0.65, respectively; P=0.009). Multivariable analysis revealed that high-dose (7.5 or 10 mg) vericiguat was independently associated with a greater reduction in log-transformed NT-proBNP at 3 months (beta=-0.125; 95% confidence interval [CI] -0.247, -0.004; P=0.043). High-dose vericiguat was not significantly associated with changes in left ventricular ejection fraction (LVEF) at 12 months (beta=0.53; 95% CI-0.49, 1.6; P=0.30). Overall, reverse remodeling at 12 months was modest (LVEF, +4.7%; left ventricular end-systolic volume index, -6.4 mL/m2) and was predominantly associated with newly initiated beta-blockers or renin-angiotensin system inhibitors within 3 months prior to vericiguat administration or prior heart failure hospitalization rather than vericiguat dose. Conclusions: In this real-world registry study, high-dose vericiguat was associated with sustained dose-dependent reductions in NT-proBNP, but not cardiac reverse remodeling.
Keywords:
Natriuretic peptide
Reverse remodeling
Vericiguat
Journal
C
IF:
3.7
Papers:
8.3K
Citations:
1.0W
Organization
Cited Papers