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Chd7 regulates lipid metabolism and swim bladder inflation in zebrafish
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DOI：10.1016/j.jlr.2026.101062.png)
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Abstract
En 中文
The chromodomain helicase remodelling enzyme, CHD7, has been directly linked to CHARGE syndrome, however recent studies show a wide variability of pathways regulated by the chromatin remodelling enzyme. Here, we show that chd7 mutant zebrafish present with a collection of dysregulated lipid metabolism enzymes in line with Pparγ regulated lipid metabolism. Consequently, we link lipid metabolism to swim bladder development and observe decreased size and non-inflated swim bladder during larval development.
Keywords:
Zebrafish
Dyslipidemia
Chd7
Swim bladder
lipid metabolism
CHARGE syndrome
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