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Chebulinic Acid Restores Glycolytic Reprogramming and Mitochondrial Dysfunction in MASLD via Modulation of Lp-PLA2 Signaling
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DOI：10.1016/j.jnutbio.2026.110475.png)
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Abstract
En 中文
• Identified a novel Lp-PLA2–HK2 regulatory axis driving metabolic dysfunction in MAFLD. • CA directly targets Lp-PLA2 with high binding affinity and improves steatosis, inflammation, and oxidative stress. • CA suppresses glycolytic reprogramming and restores mitochondrial function via HK2 downregulation. • The Glu304 residue of Lp-PLA2 is essential for CA-mediated therapeutic effects, highlighting a precise molecular target.
Keywords:
MASLD
Lp-PLA2
Chebulinic acid
HK2
Glycolytic metabolism
AAV
,
adeno-associated virus
ALT
,
alanine aminotransferase
CA
,
chebulinic acid
CAT
,
catalase
CETSA
,
cellular thermal shift assay
ECAR
,
extracellular acidification rate
FFA
,
free fatty acid
GSH-Px
,
glutathione peroxidase
HFD
,
high-fat diet
HK2
,
hexokinase 2
LDHA
,
lactate dehydrogenase A
Lp-PLA2
,
lipoprotein-associated phospholipase A2
MASLD
,
metabolic dysfunction–associated fatty liver disease
MST
,
microscale thermophoresis
OCR
,
oxygen consumption rate
PPI
,
protein–protein interaction
SOD
,
superoxide dismutase
SPR
,
surface plasmon resonance
TC
,
total cholesterol
TG
,
triglyceride
Journal
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4.9
Papers:
4.5K
Citations:
1.4W
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