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Chemical and biochemical derivates of trans-3-methylglutaconyl CoA: A molecular labyrinth
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DOI：10.1016/j.cca.2026.121060.png)
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Abstract
En 中文
• Trans 3-methylglutaconyl (3MGC) CoA is an intermediate in leucine catabolism. • Trans 3-MGC CoA can also be generated de novo from acetyl CoA. • The molecule is unstable and susceptible to spontaneous chemical reactions. • Organic acids, acylated proteins and acylcarnitines are byproducts of trans-3MGC CoA. • 3-methylglutaryl (3MG) carnitine has been correlated with acute and chronic disease.
Keywords:
trans-3-methylglutaconyl CoA
leucine catabolism
acetyl CoA
acylcarnitines
organic acids
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2.9
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1.5W
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2.1W
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