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Chemical synthesis and biological evaluation of Ectoine and its derivatives for skin-whitening, antioxidant, and UV-protective activities
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DOI：10.1016/j.jphotobiol.2025.113344.png)
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Abstract
En 中文
Ectoine (2b), a derivative of diamino acids, is widely acknowledged for its solute compatibility and finds extensive application in the formulation of cleaning products and cosmetics. At present, the production of ectoine predominantly depends on costly biotechnological fermentation methods. This study explores a novel method for the chemical synthesis of ectoine and its derivatives (2a-2e), employing diamino acid derivatives as starting materials, which achieved an impressive maximum yield of 98.18 %. The biological activities of these compounds, encompassing antioxidant, skin-whitening, and UV-protective effects, were systematically assessed. The results indicate that compounds 2a and 2b demonstrate comparable skin-whitening, antioxidant, and UV-protect.
Keywords:
Ectoine derivatives
Synthesis
Skin-whitening
Antioxidant
UV protection
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