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Chemogenetic Screen Identifies EphA2 as a Synthetic Lethal Vulnerability in MYC-Driven Triple-Negative Breast Cancer
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DOI：10.1016/j.yexcr.2026.115044.png)
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Abstract
En 中文
• Develop a chemogenetic screening platform to identify synthetic lethal compounds targeting MYC. • Identify ALW-II-41-27, an EphA2 inhibitor, as a top hit with strong MYC-selective cytotoxicity. • ALW-II-41-27 induces MYC-dependent apoptosis via the intrinsic apoptotic pathway, independent of p53 status. • In vivo, ALW-II-41-27 inhibits tumor growth in MDA-MB-231 and MDA-MB-468 TNBC xenografts without apparent toxicity.
Keywords:
MYC
EphA2
synthetic lethality
triple-negative breast cancer
ALW-II-41-27
Journal
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3.5
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1.1W
Citations:
2.0W
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