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Child-to-adult body size trajectories and risk of rheumatoid arthritis: the mediating role of metabolic unhealthiness, low-grade inflammation, and the modifying effect of genetic susceptibility
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DOI：10.1016/j.jaut.2026.103612.png)
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Abstract
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• Adult body size dominates RA risk after accounting for childhood size. • The ChildLow-AdultHigh body size trajectory confers the highest RA risk. • Low-grade inflammation is a key mediator linking body size to RA. • wt management is a central lever for RA prevention.
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