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Childhood maltreatment is linked to transdiagnostic age- and sex-specific cortical thinning and reduced amygdalar volume in young adults
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DOI：10.1016/j.euroneuro.2026.112900.png)
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Abstract
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Childhood maltreatment is a transdiagnostic risk factor, whose distributed neural correlates are most timely and urgently assessed in young adults in the earliest stages of emerging mental disorders. Here, we applied a data-driven multivariate approach to identify distributed brain structural signatures associated with childhood maltreatment, with a particular focus on limbic regions, and to examine their relevance for later functional outcomes. In a transdiagnostic sample of 251 individuals (mean age 24.9 ± 4.3, 51.8% male) with early affective or anxiety syndromes, we used a multivariate sparse partial least squares algorithm to investigate multi-layered associations between grey-matter volume and the Childhood Trauma Questionnaire.
Keywords:
Childhood maltreatment
Affective disorders
Amygdala volume
Sex differences
Sparse partial least squares
Cortical thickness
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