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Chitosan-shielded stem cell exosomes as a tight-junction-modulating bio-shuttle for enhanced transdermal delivery and skin rejuvenation
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DOI：10.1016/j.ijbiomac.2026.152484.png)
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Abstract
En 中文
• Development of chitosan-shielded exosomes (cExo) via electrostatic surface assembly. • Significant enhancement of colloidal and lyophilization stability for long-term storage. • Enhanced paracellular transport of exosomes via transient tight junction modulation. • Two-fold increase in dermal penetration confirmed by ex-vivo porcine skin assays. • Synergistic antioxidant and wound-healing effects for advanced skin-booster applications.
Keywords:
chitosan-shielded exosomes
transdermal delivery
tight junction modulation
skin rejuvenation
dermal penetration
Journal
IF:
8.5
Papers:
4.9W
Citations:
21.7W
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Cited Papers