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CHO Cell Line Selection through Multi-Criteria Analysis Reveals Critical Impact of Gas Overlay

delete2026-03-06
delete0
PRE
AI
J
Jimmy Gaudreault
P
Petko Komsalov
J
Jason Kuipers
L
Lucas Lemire
B
Brian Cass
L
Linda Lamoureux
J
Julien Leroy
C
Christopher R. Corbeil
T
Traian Sulea
R
Robert Voyer
S
Simon Joubert
Y
Yves Durocher
O
Olivier Henry *
P
Phuong Lan Pham *
DOI：10.1002/biot.70206delete
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Abstract

Abstract

En 中文
The development of robust Chinese Hamster Ovary (CHO) cell lines expressing high titers of monoclonal antibodies (MAbs) is central to bioprocess development. Following transfection and pool generation, clone selection is critical, as individual clones often behave differently in stirred-tank bioreactors.
Keywords:
Antibody Production
CHO Cells
Clone Selection
Dissolved CO2 Concentration
Fed-Batch Cell Culture
Multivariate Data Analysis (MVDA)
Overlay Air Flow
Principal Component Analysis (PCA)

Journal

Biotechnology Journal cover
Biotechnology Journal
IF:
3.1
Papers:
3.0K
Citations:
8.0K

Organization

P
polytechnique montreal
Scholars:
85
Papers: 48
Citations: 0
N
national research council canada
Scholars:
556
Papers: 219
Citations: 0