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Choice of estimands and estimators affected the interpretation of results for some outcomes in a cluster-randomised trial (RESTORE) due to informative cluster size
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DOI：10.1016/j.jclinepi.2026.112462.png)
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Abstract
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• Re-analysis of a cluster trial suggests informative cluster size for some outcomes. • The choice of estimand and estimator can affect the interpretation of results. • Trialists should define the target estimand and choose an aligned estimator.
Keywords:
Cluster randomised trial
estimand
informative cluster size
individual-average treatment effect
cluster-average treatment effect
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