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Chronic interferon signaling at baseline is associated with acquired resistance to immunotherapy in metastatic melanoma
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DOI：10.1016/j.xcrm.2026.102981.png)
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Abstract
En 中文
• A tumor purity-informed model identifies cancer cell programs from bulk RNA-seq • Chronic cancer cell interferon signaling distinguishes acquired from durable response • Dedifferentiation impairs MHC class II induction by interferon signaling in resistant tumors • Durable response associates with low intratumor heterogeneity and effector T cells
Keywords:
immunotherapy
acquired resistance
durable response
relapse
melanoma
interferon signaling
intratumor heterogeneity
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