Chrysin reprograms microglial metabolism and function via targeting SYK to alleviate the symptoms of Alzheimer's disease

2026-06-20

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Lixi Li

Yanjia Gu

Xinyue Luo

Jinyu Wang

Ying Jia *

Tingxu Yan *

DOI：10.1016/j.jep.2026.122056

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Alpiniae Oxyphyllae Fructus, first documented in Bencao Shiyi, is a classical traditional Chinese herb traditionally used to warm the kidney, invigorate the spleen, consolidate essence and relieve chronic diarrhea. Guided by the TCM theory that kidney essence nourishes brain marrow, modern studies have confirmed its notable neuroprotective and anti-neuroinflammatory activities.

Chrysin reprograms microglial metabolism and function via targeting SYK to alleviate the symptoms of Alzheimer's disease

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