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Circulating IL-17 a as a downstream inflammatory indicator of depression: Insights from mendelian randomization and animal experiments
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DOI：10.1016/j.cyto.2026.157175.png)
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Abstract
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• Enhanced secretions of circulating IL-17A and IL-1β were determined to be associated with depression risk by MR analysis. • Circulating IL-17A was suggested to be a potential pathological consequence rather than an exposure factor of depression. • CUMS-induced depressive-like syndromes in rats are IL-1β but not IL-17A-dependent.
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