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Cis-regulatory elements at cellular resolution

delete2025-09-16
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PRE
AI
Y
Yi Xiang See
T
Tim Stuart
J
Jay W. Shin *
DOI：10.1038/s41576-025-00882-7delete
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Abstract

Abstract

En 中文
Recent advances in single-cell profiling technologies now enable routine and scalable measurements of cis-regulatory element activity across diverse cell types, disease states and genetic backgrounds. It is time to coordinate a global effort to systematically map cis-regulatory element function at single-cell resolution. In this Comment, the authors outline some key next steps to advance our understanding of cis-regulatory elements at single-cell resolution, which includes harmonizing global efforts to construct a comprehensive single-cell atlas of gene regulation.
Keywords:
cis-regulatory elements
single-cell profiling
gene regulation
cellular resolution
regulatory atlas

Journal

Nature Reviews Genetics cover
Nature Reviews Genetics
IF:
52
Papers:
4.0K
Citations:
4.3W

Organization

No organization information available