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Cisplatin-induced ecDNA enhances tumor malignancy and accelerates chemoresistance acquire in gastric cancer
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DOI：10.1016/j.jare.2026.07.056.png)
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Abstract
En 中文
• Chemotherapy promoted ecDNA induction in GC, a potential mechanism that may impede therapeutic efficacy, especially in non-responding patients. • Compared to primary tumor, the proportion of ecDNA was significantly higher in metastatic tumors. • Cisplatin induced the circularization of linear DNA into ecDNA by activating the DNA damage repair pathway. • EcDNA was responsible for various promoted malignant phenotypes, which can be reversed via ecDNA inhibition. • Although ecDNA inhibitors failed to reverse pre-existing chemoresistance, they were effective in slowing the adaptation to chemotherapeutic agents.
Keywords:
Gastric cancer
Extrachromosomal DNA (ecDNA)
Chemotherapy resistance
Malignancy
Drug combination
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