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Cleavage-activatable antibody-photosensitizer conjugate enables tumor-selective photodynamic activation and immunogenic cell death
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DOI:10.1016/j.jconrel.2026.115212.png)
Abstract
En 中文
• An activatable antibody-photosensitizer conjugate was developed for PDT. • Enzyme-triggered linker cleavage switches photodynamic activity from OFF to ON. • Zwitterionic linker minimizes nonspecific serum protein interactions. • Tumor-selective activation induces spatially confined immunogenic cell death. • Precise molecular activation improves the safety of antibody phototherapy.
Journal
IF:
11.5
Papers:
1.5W
Citations:
7.4W
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