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CLIM-TIME links tumour genetics to spatial immune architecture

delete2026-06-29
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Weiwei Hu *
DOI:10.1038/s41568-026-00956-6delete
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Abstract

Abstract

En 中文
In this Tools of the Trade, Weiwei Hu describes the development and use of CLIM-TIME, a scalable in vivo platform that integrates CRISPR perturbation screens with spatially resolved transcriptomic and immune profiling to link tumour-intrinsic genetic alterations to distinct immune microenvironments.

Journal

Nature Reviews Cancer cover
Nature Reviews Cancer
IF:
66.8
Papers:
3.8K
Citations:
6.0W

Organization

C
chinese academy of sciences
Scholars:
54.9W
Papers: 44.5W
Citations: 703
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