Clinical and quality of life predictors in patients with schizophrenia with and without substance use disorder

Alvaro Gonzalez-Sanchez

doi:10.1016/j.pnpbp.2026.111734

Clinical and quality of life predictors in patients with schizophrenia with and without substance use disorder

2026-05-07

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PRE

AI

A

Alvaro Gonzalez-Sanchez

J

José Francisco Navarro

E

Erika Y. Bedoya

A

Ana Adan *

DOI：10.1016/j.pnpbp.2026.111734

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Abstract

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• SZ, SZ+, and SUD patients present distinct clinical and QoL profiles. • The SZ+ group shows high suicide risk and the worst social QoL of all groups. • Atypical antipsychotics and nicotine dependence are key predictors factors. • A machine learning model classified the groups with 97.1% accuracy.

Keywords:

schizophrenia

substance use disorder

quality of life

suicide risk

machine learning

Clinical and quality of life predictors in patients with schizophrenia with and without substance use disorder

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