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Clinical Management of Parkinson's Disease: Features, Diagnosis, and Principles of Treatment

delete2026-02-01
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PRE
AI
B
Bhavana Patel *
A
Ashley Rawls
T
Tracy Tholanikunnel
M
Michael S. Okun
DOI:10.1101/cshperspect.a041638delete
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Abstract

Abstract

En 中文
Parkinson's disease (PD) is a progressive, neurological syndrome that is associated with a plethora of motor and nonmotor symptoms. Recognizing prodromal symptoms and diagnosing PD early and accurately as well as employing timely management strategies targeting motor and nonmotor symptoms across all disease stages will have the potential to improve clinical outcomes. The application of critical advances in the field including the development of biomarkers, pharmacological treatments, exercise, and surgical therapies will be important for clinical practitioners. In this review, we will address differential diagnoses and disease mimics, as well as provide critical updates on clinical diagnosis and management strategies.
Keywords:
DEEP BRAIN-STIMULATION
MULTIPLE SYSTEM ATROPHY
CARBIDOPA INTESTINAL GEL
NONMOTOR SYMPTOMS
OLFACTORY DYSFUNCTION
ESSENTIAL TREMOR
NATURAL-HISTORY
MOTOR SYMPTOMS
LEVODOPA
SIGN

Journal

Cold Spring Harbor Perspectives in Medicine cover
Cold Spring Harbor Perspectives in Medicine
IF:
10.1
Papers:
3.0K
Citations:
1.3W

Organization

State University System of Florida cover
State University System of Florida
Scholars:
12.6W
Papers: 10.8W
Citations: 129
Cited Papers

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