Clinical significance and association with pregnancy outcome of positive non-invasive prenatal screening for trisomy 15 in singleton pregnancy: prospective cohort study, systematic review and meta-analysis

2025-10-21

PRE

Xue Sun

Yu Zheng

Yanwei Cao

Sunny Wai Hung Cheung

C. Y. Chung

Yiwei Zhao

Xiaofan Zhu

Ivan F. M. Lo

Ho‐Ming Luk

Tak Yeung Leung

Xingchen Kong *

Kwong Wai Choy *

DOI：10.1002/uog.70106

Original request for help

Save

Abstract

En 中文

To investigate the incidence and clinical significance of a positive result on genome-wide non-invasive prenatal screening (NIPS) for trisomy 15.

Keywords:

cell-free fetal DNA

confined placental mosaicism

CPM

genome-wide NIPS

NIPS

non-invasive prenatal screening

Prader–Willi syndrome

rare autosomal trisomy

RAT

TFM

trisomy 15

true fetal mosaicism

uniparental disomy 15

UPD15