Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation

Hak-Jae Kim

doi:10.1016/j.pbb.2026.174179

Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation

2026-02-26

0

PRE

AI

H

Hak-Jae Kim *

S

Shinwoo Kang

J

Jun-Tack Kwon

J

Jin Hee Kim

Y

Young Hyun Jung

M

Myeounghoon Cha

J

Jeong Beom Lee

DOI：10.1016/j.pbb.2026.174179

Original

Original request for help

Save

Abstract

En 中文

• Combined prenatal stress and MIA produces comprehensive schizophrenia-like deficits in mice. • Dual-hit offspring show impaired PPI, social behavior, and increased immobility. • Clozapine treatment during the adolescent period fully reverses behavioral abnormalities. • Prefrontal Sptan1 downregulation and Glul upregulation identified in MODEL group. • Adolescent treatment window may prevent progression of neurodevelopmental pathology.

Keywords:

schizophrenia-like deficits

prenatal stress

maternal immune activation

clozapine

adolescent treatment

Clozapine treatment during the adolescent period reverses behavioral deficits in a dual-hit mouse model combining prenatal stress and maternal immune activation

Abstract

Journal

Organization

Cited Papers

Citing Papers