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CMOS high density electrical impedance biosensor array for tumor cell detection
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DOI：10.1016/j.snb.2012.07.024.png)
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Abstract
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We present a high-throughput label-free electrical-impedance spectroscopy (EIS) platform composed of a 96 x 96 microelectrode array for counting and analysis of breast tumor cells (MCF-7). These Au-electrodes are densely packed within a 3.5 mm x 3.5 mm interrogation region. Each Au-electrode has an edge-length of 25 mu m designed to detect single tumor cell by electrical impedance spectroscopy. The detected signal is read out via an integrated circuit (IC) of addressable electrode-selection-switch array manufactured with 0.18 mu m CMOS technology. The independently addressable microelectrode array is integrated onto a printed circuit board (PCB) containing associated circuitry for electrode switching and readout. MCF-7 cells were dispensed onto the chip surface and EIS measurements were recorded before and after the cell dispensation. On an average 20% increase in impedance was found associated with cell occupancy on the electrode surface. A positive correlation was observed between cell detection with optical microscopy and with electrical scanning. (C) 2012 Elsevier B.V. All rights reserved.
Keywords:
Label free detection
Circulating tumor cells (CTCs)
Microelectrode array
Complementary metal-oxide-semiconductor (CMOS)
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