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Coassembled Peptide Nanoparticles Enable Stage-Specific Diagnosis and Targeted Therapy of Hepatic Fibrosis by Inhibiting Macrophage-Driven Inflammation

delete2026-08-07
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PRE
AI
B
B. Li
C
Chenchen Pan
Y
Yuerong Ma
J
Jianwei Bao
Q
Qianli Zou *
DOI：10.1016/j.biomaterials.2026.124530delete
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Abstract

Abstract

En 中文
• Multifunctional nanoparticles are fabricated based on coassembly of ICG and peptide. • The nanoparticles integrate theranostic and therapeutic functions for liver fibrosis. • Diagnostic window is extended and diagnostic sensitivity is improved. • Targeted therapy with the FPR2/STAT3-mediated antifibrotic mechanism is achieved. • The nanoparticles show enhanced antifibrotic efficacy with good biocompatibility.

Journal

Biomaterials cover
Biomaterials
IF:
12.9
Papers:
1.9W
Citations:
10.8W

Organization

A
anhui medical university
Scholars:
2.9W
Papers: 1.4W
Citations: 248
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