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Cobalt-catalyzed regiodivergent hydroalkenylation of alkenes
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DOI：10.1016/j.cclet.2026.112824.png)
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Abstract
En 中文
The direct hydroalkenylation of alkenes represents the most straightforward method for constructing C(sp2)-C(sp3) bonds. However, controlling chemo- and regioselectivity between two different alkenes remains a fundamental challenge. Herein, we developed a cobalt-catalyzed system to regioselectively ligate electron-deficient alkenes with electron-rich alkenes. The in-situ generated CoIII-H activate electron-deficient alkenes through a Markovnikov or anti-Markovnikov manner, to form linear or branched alkylcobalt species as key intermediate, which can successfully achieve regiodivergent hydroalkenylation of acrylates and analogs. The method demonstrates a broad substrate scope and functional group compatibility. Origin of regioselectivity control by the cobalt catalyst has been elucidated through mechanistic studies and density functional theory (DFT) calculations.
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8.9
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1.2W
Citations:
3.8W
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Cited Papers