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Cochlear Gene Therapy
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DOI：10.1101/cshperspect.a033191.png)
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Abstract
En 中文
Over 450 million people worldwide suffer from hearing loss, leading to an estimated economic burden of similar to$750 billion. The past decade has seen significant advances in the understanding of the molecular mechanisms that contribute to hearing, and the environmental and genetic factors that can go awry and lead to hearing loss. This in turn has sparked enormous interest in developing gene therapy approaches to treat this disorder. This review documents the most recent advances in cochlear gene therapy to restore hearing loss, and will cover viral vectors and construct designs, potential routes of delivery into the inner ear, and, lastly, the most promising genes of interest.
Keywords:
HAIR CELL REGENERATION
IN-VIVO DELIVERY
ADENOASSOCIATED VIRUS
HEARING-LOSS
MOUSE MODEL
ROUND-WINDOW
VESTIBULAR FUNCTION
ATOH1 GENE
INNER-EAR
NOISE EXPOSURE
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