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Cognitive reserve proxies predict cognition and motor function beyond multimodal MRI brain measures in healthy adults
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DOI：10.1016/j.biopsycho.2026.109327.png)
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Abstract
En 中文
• Cognitive reserve moderated the relationship between brain structure and outcomes • Multimodal MRI brain measures were not associated with cognitive reserve proxies • Cognitive reserve predicted cognition and motor function beyond brain measures • Cognitive reserve explained more variance in global scores than brain measures • Brain measures explained more variance in specific cognitive outcomes
Keywords:
ANOVA
Analysis of Variance
CR
Cognitive Reserve
CRIq
Cognitive Reserve Index questionnaire
CSF
Cerebrospinal Fluid
DTIFIT
Diffusion Tensor Imaging Fit
DWI
Diffusion-weighted Imaging
FA
Fractional Anisotropy
FC
Functional Connectivity
FNIRT
FMRIB’s Non-linear Image Registration Tool
FSL
FMRIB Software Library
GM
Grey Matter
IC
Independent Component
ICA
Independent Component Analysis
MCFLIRT
Motion Correction using FMRIB’s Linear Image Registration Tool
MELODIC
Multivariate Exploratory Linear Optimization for Decomposition of Independent Components
MoCA
Montreal Cognitive Assessment
MRI
Magnetic Resonance Imaging
PCA
Principal Component Analysis
pyFIX
Python implementation of functional MRI Independent Component Extraction X-classifier
rsfMRI
Resting-state Functional Magnetic Resonance Imaging
RSN
Resting-state Network
SSRT
Stop Signal Reaction Time
TBSS
Tract-based Spatial Statistics
WM
White Matter
cognitive reserve
structural MRI
diffusion MRI
functional MRI
cognition
motor function
healthy adults
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