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Cold-induced liver dysfunction drives cardiac damage through a liver–heart axis
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DOI：10.1016/j.ejphar.2026.178955.png)
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Abstract
En 中文
• Liver injury as an independent risk factor for cardiovascular diseases in cold regions. • Chronic cold exposure induces liver metabolic dysfunction and cardiac injury in mice. • Hepatocyte Cdc20 overexpression induces cardiomyocyte injury through a paracrine liver–heart axis.
Keywords:
Liver dysfunction
Cardiac damage
Cold exposure
Liver–heart axis
Hepatocyte Cdc20
Journal
IF:
4.7
Papers:
2.3W
Citations:
4.0W
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Cited Papers