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Collagen XVIIα1 in Skin and Hair Aging: Mechanisms, Stem Cell Niche Regulation, and Translational Strategies
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DOI：10.1016/j.jdermsci.2026.05.007.png)
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Abstract
En 中文
• DEJ microarchitecture places collagen XVIIα1 at the core of epidermal resilience. • Collagen XVIIα1 proteolysis links oxidative and mechanical stress to stem cell exhaustion. • Hair and skin aging converge on a collagen XVIIα1 dependent niche imbalance. • Translational avenues include protease blockade, rhCOL17 and delivery platforms. • Open questions include membrane incorporation, dosing, PK and clinical endpoints.
Keywords:
Collagen XVIIα1
Skin aging
Hair aging
Stem cell niche
Protease blockade
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3.6K
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