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Colorimetric assay based on amphiphilic polymer-coated ferrihydrite–silica microbeads for monitoring serum imatinib levels
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DOI：10.1016/j.snb.2026.139859.png)
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Abstract
En 中文
• We developed a colorimetric assay based on micro-sized beads with ferrihydrite for on-site therapeutic drug monitoring. • The micro-sized beads incorporating ferrihydrite possess enzyme-like catalytic activity and an intrinsic green coloration. • The coating of microbeads with an amphiphilic polymer effectively prevented nonspecific adsorption of contaminating proteins. • Adsorption of the analyte onto the beads suppressed the color change, and the color decreased with the analyte concentration.
Keywords:
ferrihydrite
microbeads
colorimetric assay
imatinib
serum monitoring
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