.png){kind=icon}
.png){kind=icon}
Return
Combination of rosuvastatin and curcumin outperforms monotherapies in alleviating gentamicin-induced nephrotoxicity, audiotoxicity and vestibulotoxicity in a rat animal model
.png){kind=icon}
OA
AI
T
B
B
A
J
J
D
J
A
A
DOI：10.1016/j.biopha.2025.118753.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Compared to monotherapy combination better prevented nephrotoxicity and ototoxicity. • Combination therapy synergistically prevented nephrotoxicity and early inflammation. • Rosuvastatin monotherapy was better than curcumin in preventing ototoxicity. • Curcumin monotherapy was better than rosuvastatin in preventing nephrotoxicity.
Keywords:
AKI
acute kidney injury
ALT
alanine aminotransferase
ASR
adjusted standardised residual
AST
aspartate aminotransferase
ATP
adenosine triphosphate
COMB
combination group
CPK
creatine phosphokinase
CTRL
negative control group
CUR
curcumin group
DAMPs
damage-associated molecular patterns
DMSO
dimethyl sulfoxide
G
gauge
HE
hematoxylin–eosin
HMG-CoA
3-hydroxy-3-methylglutaryl coenzyme A
i.p.
intraperitoneal
IL
interleukin
IκBα
inhibitor of NF-κB protein α
KDE
kernel density estimation [plot]
kHz
kilohertz
L
litre
LDH
lactate dehydrogenase
µm
micrometre
mL
millilitre
Model
positive control group
NAC
N-acetylcystein
NAG
N-acetyl-β-D-glucosaminidase
ng
nanogram
NGAL
neutrophil gelatinase-associated lipocalin
nmol
nanomole
p.o.
per os
PAS
periodic acid–Schiff
pg
picogram
PIP2
phosphatidylinositol 4,5-bisphosphate
RGB
red, green, blue
ROS
reactive oxygen species
RR
reduced-dose rosuvastatin group
RSD
standard-dose rosuvastatin group
TAOC
total antioxidant capacity
TNF-α
tumour necrosis factor α
U
unit
USD
United States dollar
VEGF
vascular endothelial growth factor
gentamicin
nephrotoxicity
ototoxicity
rosuvastatin
curcumin
combined therapy
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
B
IF:
7.5
Papers:
1.6W
Citations:
8.2W
Organization
Cited Papers