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Combinatorial techniques for enhancing neuroprotection Hypothermia and alkalinization

delete2010-06-17
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Damien P. Kuffler *
DOI:10.1111/j.1749-6632.2009.05353.xdelete
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Abstract

Abstract

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Brain and spinal cord (CNS) trauma typically kill a number of neurons, but even more neurons are killed by secondary causes triggered by the initial trauma. Thus, a minor insult may rapidly cause the death of a vastly larger number of neurons and complete paralysis. The best mechanism for reducing the extent of neurological deficits is to minimize the number of neurons killed by post-trauma sequelae. Neuroprotection techniques take many diverse forms with a breadth too great for a short review. Therefore, this review focuses on the neuroprotection provided by hypothermia and a number of other neuroprotective techniques, when administered singly or in combination, because it is generally found that combinations of applications lead to significantly better neuroprotection than is achieved by any one alone. The combinatorial approach to neuroprotection holds great promise for enhancing the degree of neuroprotection following trauma, leading to maximum maintenance of neurological function.
Keywords:
adult human neurons
dorsal root ganglia
hypothermia
alkalinization
ischemia
neuroprotection
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Neuroprotective Agents
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