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Combined nanodiamond-mediated drug delivery and upconversion phototherapy for enhanced liver cancer treatment
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DOI：10.1016/j.jphotobiol.2025.113260.png)
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Abstract
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• Nanodiamond (ND) with upconversion nanoparticles (UCNPs) was proposed for HepG2 liver cancer treatment. • NDs enable a high local concentration of DOX, and UCNPs trigger the blue light for boosting ROS generation. • In vitro and in vivo examinations indicate significant anticancer effects from combined chemotherapy and photodynamic therapy. • No observable toxicity or tissue damage in major organs was found, supporting clinical safety.
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