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Communicating with Hedgehogs
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DOI：10.1038/nrm1622.png)
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Abstract
En 中文
Signalling by secreted Hedgehog (Hh) proteins is important for the development of many tissues and organs. Damage to components of the Hh signal-transduction pathway can lead to birth defects and cancer. The Hh proteins are distributed in tissues in a gradient, and cells respond to different thresholds of Hh with distinct responses. The cellular machinery that is responsible for the unique molecular mechanisms of Hh signal transduction has been largely conserved during metazoan evolution.
Keywords:
KINESIN-RELATED PROTEIN
STEROL-SENSING DOMAIN
ZINC-FINGER PROTEIN
PICK C1 PROTEIN
SONIC-HEDGEHOG
SIGNAL-TRANSDUCTION
CUBITUS INTERRUPTUS
NEGATIVE REGULATOR
SUBCELLULAR-LOCALIZATION
DROSOPHILA ORTHOLOG
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