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Comorbidity patterns and immune-metabolic differences in patients with acute depressive episodes
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DOI：10.1016/j.comppsych.2026.152729.png)
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Abstract
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• The study identified four latent classes of comorbidity in depression: metabolic abnormalities, mixed cardiovascular, anxiety with thyroid dysfunction, and anxiety-only. • The metabolic and cardiovascular clusters exhibited a high-inflammation phenotype (elevated SII), while the anxiety and thyroid clusters displayed a low-inflammation or endocrine-driven phenotype.
Keywords:
Depression
Comorbidity
Latent class analysis
Inflammation
Metabolic syndrome
Biomarkers
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