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Comparative Analysis of Bone Remodeling Dynamics and Bone Vitality Following Standard Bone Augmentation Procedures: A Review
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DOI：10.3390/jfb17080398.png)
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Abstract
En 中文
Bone augmentation procedures are widely used in implant dentistry to reconstruct deficient alveolar bone and support implant placement. However, outcomes are often evaluated mainly by defect filling, volumetric stability, or implant survival, which do not necessarily reflect the biological quality of regenerated tissue. This narrative review synthesizes human and supporting mechanistic evidence across autogenous, allogeneic, xenogeneic, and alloplastic grafts, including biologically functionalized constructs, with emphasis on bone remodeling dynamics and functional regeneration. Available evidence indicates that volumetric preservation alone should not be considered equivalent to complete bone regeneration and that remodeling is material-, product-, processing-, and indication-dependent. Augmented sites may contain newly formed vital bone together with persistent residual graft particles, forming a hybrid tissue whose significance depends on graft integration, vascularization, remodeling capacity, and the intended therapeutic objective. Persistent particles may influence the local immune microenvironment and, under unfavorable conditions, contribute to foreign body reactions or other complications, although such events appear uncommon and causal relationships remain uncertain. Biomaterial assessment should integrate quantitative, structural, and biological parameters, while residual graft persistence should be interpreted in an indication-specific manner rather than as evidence of treatment failure or inferior long-term performance in isolation.
Keywords:
bone augmentation
dental biomaterials
bone remodeling
vital bone
allografts
biological functionalization
residual graft material
xenografts
alloplastic bone substitutes
histomorphometry
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