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Comparative evaluation of three mechanical injury models for caudal intervertebral disc degeneration in Sprague–Dawley rats: Percutaneous needle puncture, blade incision, and microsurgery-assisted annular injury

delete2026-05-05
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PRE
AI
C
Chao Chen
Q
Qianlin Zuo
Q
Qicong He
Z
Zijiu Yangyang
G
Guishuai Wu
H
Haoyan Luo
Z
Zhendao Li
R
Renzhong Yang
M
Muheng He
Y
Yi Yang *
F
Fan Zhang *
DOI：10.1016/j.tice.2026.103573delete
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Abstract

Abstract

En 中文
• Three rat caudal IDD models, PNP, BI and MFA, were directly compared at the same disc level. • X-ray, MRI, histology, IF and IHC were used to assess structural and matrix changes in each model. • BI induced the fastest and most severe degeneration, with disc height loss, MMP13 increase and COL2A depletion. • PNP caused moderate-to-severe degeneration, while MFA showed slower and milder matrix degeneration. • These data guide model selection for late-stage IDD, early degeneration and regenerative therapy studies.
Keywords:
Intervertebral disc degeneration
Rat model
Mechanical injury
Disc height loss
Matrix degradation

Journal

Tissue and Cell cover
Tissue and Cell
IF:
2.5
Papers:
867
Citations:
4.1K

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