.png){kind=icon}
.png){kind=icon}
Return
Comparative network pharmacology analysis of ketamine and xanomeline in major depressive disorder: Shared and distinct molecular mechanisms
.png){kind=icon}
PRE
AI
X
K
J
DOI：10.1016/j.pnpbp.2026.111727.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Xanomeline and ketamine showed both shared and distinct molecular networks in MDD. • EGFR, IGF1R, and SRC were identified as common core targets of both drugs. • Xanomeline was linked to receptor tyrosine kinase/PI3K–AKT signaling, whereas ketamine was linked to glutamatergic/NMDA-related pathways. • Docking analysis supported partial convergence on shared plasticity-related signaling nodes
Keywords:
Xanomeline
Ketamine
Major depressive disorder
Molecular mechanisms
Network pharmacology
Journal
P
IF:
3.9
Papers:
6.6K
Citations:
1.4W
Organization
Cited Papers