Comparison of ephedrine and phenylephrine use on postoperative acute kidney injury in elective noncardiac surgery: A retrospective cohort study

Ah Ran Oh

doi:10.1016/j.jclinane.2026.112244

Comparison of ephedrine and phenylephrine use on postoperative acute kidney injury in elective noncardiac surgery: A retrospective cohort study

2026-06-08

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A

Ah Ran Oh *

J

Ji Won Lee

C

Chisong Chung

D

Duk Kyung Kim

DOI：10.1016/j.jclinane.2026.112244

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Abstract

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• This study compares the impact of intraoperative ephedrine versus phenylephrine on postoperative acute kidney injury (AKI) after elective noncardiac surgery. • Intraoperative phenylephrine was associated with a higher risk of developing postoperative AKI than ephedrine. • This suggests that intraoperative vasopressor choice may be a modifiable factor in improving postoperative renal outcome.

Keywords:

Acute kidney injury

Creatinine

Ephedrine

Phenylephrine

Surgery

Vasoconstrictor agents

Comparison of ephedrine and phenylephrine use on postoperative acute kidney injury in elective noncardiac surgery: A retrospective cohort study

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