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Complement contributes to hyperactive behavior in the 16p11.2 hemideletion mouse model
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DOI：10.1016/j.bbi.2026.106552.png)
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Abstract
En 中文
• 16p11.2 hemideletion (16p11.2 del) increases complement expression in the striatum. • Blocking C3aR signaling ameliorates hyperactivity in 16p11.2 del model mice. • C3aR antagonist reduces interferon stimulated gene levels in 16p11.2 del striatum.
Keywords:
16p11.2
Neurodevelopmental disorders
Complement
Hyperactivity
Microglia
Striatum
Inflammation
Interferon
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