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Complement deficiencies and infections
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DOI：10.1016/j.coi.2025.102711.png)
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Abstract
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• Inherited complement deficiencies confer high risk of severe bacterial infections. • Classical pathway defects predispose to SLE and encapsulated bacterial infections. • C3 and regulatory protein deficiencies impair opsonization and immune regulation. • Terminal pathway deficiencies increase susceptibility to Neisseria infections. • Anti-complement therapies require vigilant monitoring for infections.
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