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Complement System-Mediated Immunomodulation in Epilepsy: From Pathogenesis to Therapeutic Opportunities

delete2026-06-10
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PRE
AI
L
Linqian Peng
M
Mengxuan Lu
M
Mingyue Chen
R
Rongchuan Liu
S
Shuang Xia *
G
Guohe Tan *
DOI：10.1016/j.neuint.2026.106200delete
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Abstract

Abstract

En 中文
• 1.Complement activation participates in epileptogenesis and seizure aggravation • 2.C1q–C3 signaling mediates aberrant synaptic pruning in epileptic networks • 3.Glial complement signaling links neuroinflammation to neuronal hyperexcitability • 4Complement components serve as candidate biomarkers for epilepsy • 5.Targeting complement offers potential immunomodulatory strategies for epilepsy

Journal

Neurochemistry International cover
Neurochemistry International
IF:
4
Papers:
5.3K
Citations:
1.0W

Organization

G
GuangXi Medical University
Scholars:
2.3K
Papers: 507
Citations: 3.1K
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