Complement: The Road Less Traveled

doi:10.4049/jimmunol.2200540

Complement: The Road Less Traveled

2023-01-15

24

OA

AI

DOI：10.4049/jimmunol.2200540

Original

Original request for help

Save

Abstract

En 中文

The complement field has recently experienced a strong resurgence of interest because of the unexpected discovery of new complement functions extending complement's role beyond immunity and pathogen clearance, a growing list of diseases in which complement plays a role, and the proliferation of complement therapeutics. Importantly, although the majority of complement components in the circulation are generated by the liver and activated extra-cellularly, complement activation unexpectedly also occurs intracellularly across a broad range of cells. Such cell -autonomous complement activation can engage intracellu-lar complement receptors, which then drive noncanonical cell-specific effector functions. Thus, much remains to be discovered about complement biology. In this brief review, we focus on novel noncanonical activities of complement in its classic areas of operation (kidney and brain biology, infection, and autoimmunity), with an outlook on the next generation of complement-targeted therapeutics.

Keywords:

CANDIDA-ALBICANS

FACTOR-H

INTRACELLULAR COMPLEMENT

RHEUMATOID-ARTHRITIS

REGULATORY PROTEINS

CELLS

EXPRESSION

ACTIVATION

KIDNEY

PROLIFERATION

Complement: The Road Less Traveled

Abstract

Journal

Organization