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Complementary body weight and cardiometabolic benefits of higher GLP-1 and lower GIP: Genetic evidence from large-scale phenomic analyses
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DOI：10.1016/j.metabol.2026.156711.png)
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Abstract
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• Clinically significant effects of either genetically predicted higher GLP-1 and/or lower GIP levels concerning cardio renal liver metabolic diseases were observed. • Joint genetic elevation of GLP-1 and reduction of GIP levels result in complementary and additive beneficial effects, conferring benefits in terms of body weight regulation and cardio renal liver metabolic diseases. • Low-level GIP may exert its cardiovascular benefits primarily through reducing body weight.
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