Complex subtelomeric architectures in a complete rhesus macaque reference genome

Shilong Zhang

doi:10.1016/j.cell.2026.02.018

Complex subtelomeric architectures in a complete rhesus macaque reference genome

2026-08-06

0

PRE

AI

Alessandra La Torraca

DOI：10.1016/j.cell.2026.02.018

Original

Original request for help

Save

Abstract

En 中文

• A complete, near-perfect rhesus macaque genome is enabled by improved long-read assembly • Sequencing biases within repeats are the major barrier to the highest genome accuracy • Macaque subtelomeres harbor highly organized structures distinct from those in hominids • Resolving complex regions reveals previously inaccessible genes and regulatory elements

Keywords:

telomere-to-telomere genome assembly

complete genome

long-read sequencing

sequencing bias

subtelomeric architecture

primate evolution

duplicated genes

repeat elements

genome organization

Complex subtelomeric architectures in a complete rhesus macaque reference genome

Abstract

Journal

Organization