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Composite endpoints
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DOI：10.1016/j.jclinepi.2020.07.017.png)
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Abstract
En 中文
Studies often combine several events, for example, death or myocardial infarction or stroke, into a single study outcome. This is called a composite endpoint. Composite endpoints make doing trials easier by reducing the sample size or follow-up period required to demonstrate the effectiveness of an intervention. However, interpreting the results of composite endpoints can be confusing. To avoid misleading conclusions about the effectiveness of an intervention, it is important for readers of studies reporting a composite endpoint to ascertain that the clinical importance, the frequency of events, and the effect of the intervention on each component of the composite endpoint are similar. (C) 2020 Elsevier Inc. All rights reserved.
Keywords:
Composite endpoint
Clinical trial
Treatment effect
Primary endpoint
randomized controlled trial
Outcome measures
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