Comprehensive Performance Testing and External Validation of an AI Algorithm to Detect and Segment Brain Metastases

2026-07-08

PRE

Rupesh Kotecha, MD *

Eyub Y Akdemir, MD

Naseem Ud Din, PhD

Sreenija Yarlagadda, MD

Mauricio Reyes, PhD

Francesco Nitti

Alonso N Gutierrez, PhD, MBA

D Jay M Wieczorek, PhD

Yongsook C Lee, PhD

Ranjini Tolakanahalli, PhD

Evan D Bander, MD

Michael W Mcdermott, MD

Manmeet S Ahluwalia, MD

Minesh P Mehta, MD

DOI：10.1093/neuonc/noag152

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Artificial intelligence (AI)-based models have shown initial promise in imaging brain metastasis; however many lack validation against advanced imaging-informed datasets, precluding external validity and limiting widespread adoption. To overcome these limitations, we performed comprehensive performance testing against reference standard metrics and externally validated an AI algorithm.

Comprehensive Performance Testing and External Validation of an AI Algorithm to Detect and Segment Brain Metastases

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