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Comprehensive transcriptome sequencing and biochemical studies revealed that acrolein induced lung injury in BEAS-2B cells and male rats through the lncRNA MIR155HG/miR-155-5p/CD200R1 and Nrf2/SLC7A11/GPX4 ferroptosis pathways
10.1016/j.redox.2025.103832
2025-08-20
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• Significant change of 636 lncRNAs and 214 mRNAs were first reported after acrolein exposure. •BEAS-2B cells and lung injury caused by acrolein was proven to be related to ferroptosis. •Acrolein exacerbated lipid peroxidation of cell membrane by inhibiting the expression of GPX4 protein. •LncRNA-MIR155HG/miR-155-5p/CD200R1 axis played a vital role in acrolein-induced ferroptosis. •Inhibition of ferroptosis might be a potential therapy to relieve acrolein-induced lung injury.
Keywords:
Acrolein
Lung injury
Transcriptome sequencing
LncRNA MIR155HG
Lipid peroxidation
Ferroptosis
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Dan Liu
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Hui Yu
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Zhicun Liu
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Le Wang
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Dawo Liu
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liaoning university
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