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Concept and connotation of the geroprotective and anti-aging effects of metformin: From AMPK Activation to SASP Suppression
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DOI：10.1016/j.mce.2026.112802.png)
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Abstract
En 中文
• Metformin targets aging hallmarks via AMPK activation and mTORC1 inhibition. • The drug restores mitophagy and reduces systemic inflammaging and SASP. • Clinical data link metformin to lower all-cause mortality and dementia. • Metformin restores gut dysbiosis by improving bacterial taxonomy, bacterial functions, and metabolomics
Keywords:
Metformin
AMPK activation
mTORC1 inhibition
inflammaging
SASP suppression
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